45.       Englezos D., C. Voutouri, and T. Stylianopoulos. Machine learning analysis for the impact of tumor stiffness and perfusion on cancer treatment efficacy. Translational Oncology [DOI: 10.1016/j.tranon.2024.101944]

44.       Mpekris F., Panagi M., Charalambous A., Voutouri C., and T. Stylianopoulos. May the force NOT be with you: Therapeutic strategies to modulate cancer mechanopathology and enhance immunotherapy. Cell Reports Medicine (Accepted).

43.       Mpekris F., M. Panagi, C. Michael, C. Voutouri, M. Tsuchiya, C. Wagatsuma, H. Kinoh, A. Osada, S. Akinaga, S. Yoshida, J.D. Martin and T. Stylianopoulos. Translational nanomedicine potentiates immunotherapy in sarcoma by normalizing the microenvironment. Journal of Controlled Release [DOI: 10.1016/j.jconrel.2022.12.016]

42        Stylianou, A., Voutouri, C., Mpekris, F., & Stylianopoulos, T. (2023). Pancreatic Cancer Presents Distinct Nanomechanical Properties During Progression. Annals of Biomedical Engineering. [DOI: 10.1007/s10439-023-03168-3]

41.       Mpekris F., Panagi M., Charalambous A., Voutouri C., Michael C., Papoui A., and T. Stylianopoulos. A synergistic approach for modulating the tumor microenvironment to enhance nano-immunotherapy in sarcomas. Neoplasia [DOI: 10.1016/j.neo.2024.100990].

40.       Panagi M., F. Mpekris, C. Voutouri, A. Hadjigeorgiou, C. Michael, A. Stylianou, A. Constantinidou, J. Martin, H. Cabral, and T. Stylianopoulos. Reprogramming tumor resident mast cells restores T cell infiltration and sensitizes sarcomas to PD-L1 inhibition. Clinical Cancer Research. [DOI: 10.1158/1078-0432.CCR-24-0246].

39.       Voutouri C., D. Englezos, C. Zamboglou, I Strouthos, G. Papanastasiou, and T. Stylianopoulos. A prognostic convolutional attention model for predicting tumor response to chemo-immunotherapy from ultrasound elastography. Communications Medicine (In Revision)

38.       Voutouri C., C.C. Hardin, V. Naranbhai, M.R. Nikmaneshi, M.J. Khandekar, J.F. Gainor, L.L. Munn, R.K. Jain and , T. Stylianopoulos. Dynamic heterogeneity in COVID-19: Insights from a mathematical model. PlosOne [DOI: 10.1371/journal.pone.0301780]

37.      Charalambous A., Mpekris F., Panagi M., Voutouri C., Michael C., Gabizon A., and T. Stylianopoulos. Tumor microenvironment reprogramming improves nanomedicine-based chemo-immunotherapy in sarcomas. Molecular Cancer Therapeutics (Accepted)

36.      Christofidou D.E., M. Tomazou , C. Voutouri, C. Michael, T. Stylianopoulos, G.M. Spyrou, and K. Strati. Oct4 is a gatekeeper of epithelial identity by regulating cytoskeletal organization in skin keratinocytes. Cell Reports [DOI: 10.1016/j.celrep.2024.113859]

35.      Voutouri C., C.C. Hardin, V. Naranbhai, M.R. Nikmaneshi, M.J. Khandekar, J.F. Gainor, T. Stylianopoulos, L.L. Munn, and R.K. Jain. In silico clinical studies for the design of optimal COVID-19 vaccination schedules in patients with cancer. Cell Reports Medicine [DOI: 10.1016/j.xcrm.2024.101436]

34.      Mpekris F., Papaphilippou C.P., Panagi M., Voutouri C., Michael C., Marinov D.M., Katsioloudi A., Prokopi D.M., Anayiotos A., Cabral H., Krasia C.T., and Stylianopoulos T. Pirfenidone-loaded polymeric micelles as an effective mechanotherapeutic to potentiate immunotherapy in mouse breast cancer models. ACS Nano [DOI: 10.1021/acsnano.3c03305].

33.        Voutouri C., F. Mpekris, M. Panagi, C. Krolak, C. Michael, J.D. Martin, M.A. Averkiou and T. Stylianopoulos. Ultrasound stiffness and perfusion markers correlate with tumor volume responses to immunotherapy. Acta Biomaterialia. [DOI: 10.1016/j.actbio.2023.06.007]

32.         Panagi M., F. Mpekris, P. Chen, C. Voutouri, Y. Nakagawa, J.D. Martin, T. Hiroi, H. Hashimoto, P. Demetriou, C. Pierides, R. Samuel, A. Stylianou, C. Michael, S. Fukushima, P. Georgiou, P. Papageorgis, P.Ch. Papaphilippou, L. Koumas, P. Costeas, G. Ishii, M. Kojima, K. Kataoka, H. Cabral and T. Stylianopoulos. Polymeric micelles effectively reprogram the tumor microenvironment to potentiate nano-immunotherapy in mouse breast cancer models. Nature Communications. [DOI: 10.1038/s41467-022-34744-1]

31.         Stylianou A., F. Mpekris, C. Voutouri, A. Papoui, A. Constantinidou, E. Kitiris, M. Kailides, and T. Stylianopoulos. Nanomechanical properties of solid tumors as treatment monitoring biomarkers. Acta Biomaterialia. [DOI: 10.1016/j.actbio.2022.10.021]

30.         Mpekris F., C. Voutouri, M. Panagi, J.W Baish, R.K Jain, & T. Stylianopoulos. Normalizing tumor microenvironment with nanomedicine and metronomic therapy to improve immunotherapy. Journal of Controlled Release. [DOI: 10.1016/j.jconrel.2022.03.008]

29.         C. Voutouri, C.C. Hardin, V. Naranbhai, M.R. Nikmaneshi, M.J. Khandekar, J.F. Gainor, T. Stylianopoulos, L.L. Munn and R.K. Jain. Requirement for booster doses in healthy, cancer and immunosuppressed patients infected with the ancestral or variant SARS-CoV-2. (Under review)

28.         Subudhi S.*, C. Voutouri*, C.C. Hardin, M.R. Nikmaneshi, A.B. Patel, A. Verma, M. Khadekar, S. Dutta, T. Stylianopoulos, R. K. Jain and L.L. Munn. Strategies to Minimize Heterogeneity and Optimize Clinical Trials in Acute Respiratory Distress Syndrome (ARDS): Insights from Mathematical Modeling. eBioMedicine [DOI: 10.1016/j.ebiom.2021.103809]. *equal work

27.         Voutouri C., M.R. Nikmaneshi, C.C. Hardin, A.B. Patel, A. Verma, M. Khadekar, S. D., T. Stylianopoulos, L.L. Munn and R.K. Jain. In silico dynamics of COVID-19 phenotypes for optimizing clinical management. PNAS [DOI: 10.1073/pnas.2021642118].

26.         Voutouri C., Panagi M., Mpekris F., Demetriou P., Pierides C., Koumas L., Costeas P., Martin JD, and T. Stylianopoulos. Bosentan normalizes the breast tumor microenvironment to improve immune checkpoint inhibition. Advanced Therapeutics [DOI: 10.1002/adtp.202000289].

25.         Voutouri C., I. Tsitsipanis and T. Stylianopoulos. Swelling behavior of cornea and articular cartilage: the role of hyaluronan and collagen (Under review).

24.         Mpekris F., M. Panagi, C. Voutouri, J.D. Martin, R. Samuel, S. Takahashi, N. Gotohda, T. Suzuki, P. Papageorgis, P. Demetriou, C. Pierides, L. Koumas, P. Costeas, M. Kojima, G. Ishii, A. Constantinidou, K. Kataoka, H. Cabral, and T. Stylianopoulos. Normalizing the microenvironment overcomes vessel compression and resistance to nano-immunotherapy in breast cancer lung metastasis. (2020) Advanced Science [DOI: 10.1002/advs.202001917].

23.         Martin J.D., M. Panagi,A. Hosoi, T.T. Khan, M.R. Martin, F. Mpkeris, K. Nagaoka, D. Cheng, C. Voutouri, M. Louca, P. Papageorgis, N. Nitta, I. Aoki, K. Kataoka, K. Kakimi, T. Stylianopoulos, and H. Cabral, Dexamethasone increases efficacy of immune checkpoint blockade in metastatic triple negative breast cancer by normalizing the microenvironment. (Under review).

22.         Karagiorgis S., Tsamis A., C. Voutouri, Turcu R., Porav S., Socoliuc V.M., Vekas L., Louca M., Stylianopoulos T., Vavourakis V, and Krasia-Christoforou T., Engineered magnetoactive collagen hydrogels with tunable and predictable mechanical response (2020). Materials Science & Engineering C. 114:111089 [DOI: 10.1016/j.msec.2020.111089].

21.         Katsamba I., P. Evangelidis, C. Voutouri, A. Tsamis, V. Vavourakis and T. Stylianopoulos. Biomechanical modelling of spinal tumor anisotropic growth (2020). Proc. R. Soc. A. 476:20190364 [DOI: 10.1098/rspa.2019.0364]

20.         Mpekris F., C. Voutouri, J.W. Baish, D.G. Duda, L.L. Munn, T. Stylianopoulos, R.K. Jain. Combining microenvironment normalization strategies to improve cancer immunotherapy (2020). PNAS 117:3728-3737 [DOI: 10.1073/pnas.1919764117]

19.         Gkretsi V., A. Stylianou, M. Kalli, M. Louca, C. Voutouri, A. Zaravinos and T. Stylianopoulos. Growth Silencing of Growth Differentiation Factor-15 Promotes Breast Cancer Cell Invasion by Down-regulating Focal Adhesion Genes (2020). Anticancer Research 40:1375-1385 [DOI: 10.21873/anticanres.14079].

18.         Panagi M*, Voutouri C*, Mpekris F, Papageorgis P, Martin MR, Martin JD, Demetriou P, Pierides C, Polydorou C, Stylianou A, Louca M, Koumas L, Costeas P, Kataoka K, Cabral H, Stylianopoulos T. TGF-β inhibition combined with cytotoxic nanomedicine normalizes triple negative breast cancer microenvironment towards anti-tumor immunity (2020). Theranostics 10:1910 [DOI: 10.7150/thno.36936]. *equal work

17.         Kalli M., C. Voutouri, A. Minia, V. Pliaka, C. Fotis, L.G. Alexopoulos, and T. Stylianopoulos. Mechanical Compression inhibits the growth of brain cancer cell spheroids and regulates cell migration through MEK1/Erk1 pathway and GDF15 expression (2019). Frontiers in oncology 9:992 [DOI: 10.3389/fonc.2019.00992].

16.         Martin J.D., M. Panagi, C. Wang, T.T. Khan, M.R. Martin, C. Voutouri, K. Toh, P. Papageorgis, F. Mpekris, C. Polydorou, G. Ishii, S. Takahashi, N. Gotohda, T. Suzuki, M.E. Wilhelm, V.A. Melo, S. Quader, J. Norimatsu, R.M. Lanning, M. Kojima, M.D. Stuber, T. Stylianopoulos, H. Cabral, and K. Kataoka and H. Cabra. Dexamethasone increases cisplatin-loaded nanocarrier delivery and efficacy in metastatic breast cancer by normalizing the tumor microenvironment (2019). ACS nano 13:6396-6408 [DOI: 10.1021/acsnano.8b07865].

15.         Voutouri C., N.D. Kirkpatrick, E. Chung, F. Mpekris, J.W. Baish, L.L. Munn, D. Fukumura, T. Stylianopoulos and R.K. Jain. Dynamics of vessel cooption in brain tumors revealed by integrative experimental and mathematical modeling studies (2019). PNAS 116:2662-2671 [DOI: 10.1073/pnas.1818322116].

14.         Kitiri E.N., C.K. Varnava, C.S. Patrickios, C. Voutouri, T. Stylianopoulos, M. Gradzielski and I. Hoffmann. Double-networks Based on Interconnected Amphiphilic “In-out” Star First Polymer Conetworks Prepared by RAFT Polymerization (2018). Journal of Polymer Science, Part A: Polymer Chemistry. 56:2161-2174 [DOI: doi.org/10.1002/pola.29176]

13.         Papaparaskeva G., C. Voutouri, V. Gkretsi, M. Achilleos, T. Stylianopoulos and T. Krasia-Christoforou. Tuning the Mechanical Properties of BIEE-crosslinked Semi-Interpenetrating, Double-Hydrophilic Hydrogels (2018). Macromolecular Materials and Engineering 303:1700643 [DOI: 10.1002/mame201700643].

12.         Mpekris F.*, C. Voutouri*, P. Papageorgis and T. Stylianopoulos. Stress alleviation strategy in cancer treatment: Insights from a mathematical model (2018). Z Angew Math Mech. 98:2295-2306 [DOI: 10.1002/zamm.201700270]. *equal work

11.         Voutouri C. and T. Stylianopoulos. Accumulation of mechanical forces in tumors is related to hyaluronan swelling and tissue stiffness (2018). PLoS One 13: e0193801 [DOI: 10.1371/journal.pone.0193801].

10.         Mpekris F., P. Papageorgis, C. Polydorou, C. Voutouri, M. Kalli, A.P. Pirentis and T. Stylianopoulos. Sonic-hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo- and nanotherapy (2017). Journal of Controlled Release 261: 105-112. [DOI: 10.1016/j.jconrel.2017.06.022]

9.            Papageorgis P., C. Polydorou, F. Mpekris, C. Voutouri, E. Agathokleous, C. P. Kapnissi-Christodoulou, and T. Stylianopoulos. Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo- and nanotherapeutics in a size-independent manner (2017). Scientific Reports 7:46140. [DOI: 10.1038/srep46140]

8.            Polydorou C., F. Mpekris, P. Papageorgis, C. Voutouri, and T. Stylianopoulos. Pirfenidone normalizes the tumor microenvironment to improve chemotherapy (2017). Oncotarget 8:24506-24517. [DOI: 10.18632/oncotarget.15534]

7.            Voutouri C., C. Polydorou, P. Papageorgis, V. Gkretsi, and T. Stylianopoulos. Hyaluronan-derived swelling of solid tumours, the contribution of collagen and cancer cells, and implications for cancer therapy (2016). Neoplasia 18: 732-741. [DOI: 10.1016/j.neo.2016.10.001]

6.            Kitiri E., C. Patrickios, C. Voutouri, T. Stylianopoulos, I. Hoffmann, R. Schweins, and M. Gradzielski. Synthesis and characterization of double-networks based on pH-responsive, amphiphilic "core-first" star first polymer conetworks prepared by sequential RAFT polymerization (2016). Polymer Chemistry 8:245-259 [DOI: 10.1039/C6PY01340F]

5.            Wijeratne P.A., V. Vavourakis, J.H. Hipwell, C. Voutouri, P. Papageorgis, T. Stylianopoulos, A. Evans, and D.J. Hawkes. Multiscale modelling of solid tumour growth: the effect of collagen micromechanics (2016). Biomechanics and Modeling in Mechanobiology 15:1079-1090 [DOI: 10.1007/s10237-015-0745-2]

4.            Kepola E.J, E. Loizou, C.S. Patrickios, E. Leontidis, C. Voutouri, T. Stylianopoulos, R. Schweins, M. Gradzielski, C. Krumm, J.C. Tiller, M. Kushnir, and C. Wesdemiotis. Amphiphilic polymer conetworks based on end-linked “core-first” star block copolymers: structure formation with long-range order (2015). ACS Macro Letters 4:1163-1168 [DOI: 10.1021/acsmacrolett.5b00608]

3.            Pirentis A.P., C. Polydorou, P. Papageorgis, C. Voutouri, F. Mpekris, and T. Stylianopoulos. Remodelling of extracellular matrix due to solid stress accumulation during tumour growth (2015). Connective Tissue Research 56:345-354. [DOI: 10.3109/03008207.2015.1047929]

2.            Voutouri C., and T. Stylianopoulos. Evolution of osmotic pressure in solid tumors (2014). Journal of Biomechanics 47:3441-3447 [DOI: 10.1016/j.jbiomech.2014.09.019]

1.            Voutouri C., F. Mpekris, P. Papageorgis, A.D. Odysseos, and T. Stylianopoulos. The role of constitutive behavior and tumor-host mechanical interactions in the state of stress and growth of solid tumors (2014). PLoS One 9(8): e104717 [DOI: 10.1371/journal.pone.0104717]